Anhedonia is a severely debilitating hallmark feature of Major Depressive Disorder (MDD) and a symptom which is often difficult to treat. Snaith-Hamilton Pleasure Scale (SHAPS), a validated 14-question self-assessment for anhedonia, was collected in a naturalistic setting before and after TMS for treatment-resistant MDD. TMS resulted in a significant improvement in hedonic drive from pre to post TMS overall. Patients whose MDD met response criteria had a significantly greater degree of improvement in hedonic drive. However, baseline anhedonia severity was not a predictor of TMS clinical response.
Dr. Kozel is the Director of the TMS Clinic and Staff Psychiatrist in Mental Health and Behavioral Sciences (MH&BS) at the James A. Haley Veteran's Hospital; as well as Professor, Department of Psychiatry and Behavioral Sciences, University of South Florida. Dr. Kozel's work with neuromodulation techniques like TMS has included research, clinical care, teaching, and dissemination for over 20 years. His research uses brain imaging and brain stimulation to better understand and treat neuropsychiatric disorders with the focus of improving the lives of patients with these disorders.