Precision Organizational and Functional Estimates for TMS Targeting

You’re invited to join the Clinical TMS Society for this installment of our Grand Rounds Webinar Series: Precision Organizational and Functional Estimates for TMS Targeting featuring Dr. Mark Eldaief!

Network models are increasingly invoked to characterize the neurobiological underpinnings of mental illnesses. Dysfunction within specific networks (e.g., the default, salience and control networks) promotes the formation of specific symptoms. This suggests an opportunity to treat specific depressive symptoms by modulating specific circuits with transcranial magnetic stimulation (TMS). In this talk, I will review our project which uses precision MRI methods to delineate cortical networks in the individual at high resolution and to then stimulate specific networks in separate sessions with TMS. We will then survey the differential impact of network-specific stimulation with REST-BOLD and TASK-BOLD imaging as well as with validated state-based questionnaires and brief neuropsychological tests. This work will facilitate individualized neuromodulation approaches based on network topography. This will pollinate large-scale clinical trials assessing the effects of differential circuit modulation. It will also illuminate circuit-construct relationships across neuropsychiatric disorders.

At the end of this presentation participants will be able to:

  1. describe the network basis of specific psychopathological symptoms in depression.
  2. identify the use of precision MRI to define cortical networks in the individual.
  3. list the methods of applying TMS to specific networks in the individual to modulate specific symptom domains.

1 Hour CME Credit available

Format: On-Demand

Cost: Members: $25 | Non-members $50 | Student Members FREE


Mark Eldaief, MD

Dr. Eldaief attended medical school at Columbia University. Following this, he did a combined residency in Neurology and Psychiatry at Columbia and a Research Fellowship in Cognitive Neurology at the Beth Israel Deaconess Medical Center. He is now an Assistant Professor of Neurology at Harvard Medical School and is a staff neurologist and psychiatrist at the Massachusetts General Hospital.