Controlling Brain State Variability to Optimize rTMS Efficacy

The Clinical TMS Society presents this installment of our Grand Rounds Webinar Series: Controlling Brain State Variability to Optimize rTMS Efficacy featuring Speaker: Lysianne Beynel, PhD

In this presentation, we will explore the pivotal role of brain state variability in influencing basic TMS outcomes like MEP and phosphenes. We will then focus on some clinical applications that used control of state-dependency as a proof of principle. Finally, in a demonstration of a specific case of state-dependency control, we will uncover the potential synergy between rTMS and cognitive therapy in 
improving depression treatment, as a way to pave the way for more personalized and effective therapies.

At the end of this presentation participants will be able to:
• Demonstrate how varying brain states affect basic TMS measures like motor 
evoked potentials (MEPs) and phosphenes. 
• Evaluate the impact of controlling brain state on improving rTMS outcomes as 
a proof of principle. 
• Examine the potential benefits of combining rTMS with cognitive therapy for 
treating depression in this context.

Take advantage of our live Q&A session at the conclusion of the webinar!

1 Hour CME Credit available

Format: On-Demand

Cost: Members: $25 | Non-members $50 | Student Members FREE

Speaker: Lysianne Beynel, PhD

Dr. Beynel completed her PhD at University Grenoble Alpes in France where she 
investigated the effects of transcranial magnetic stimulation (TMS) on bipolar 
disorders. She then moved to Duke University for her post-doc work, where she 
investigated the use of rTMS in improving working memory in older adults. Her 
research, at that time, was mainly focused on the effects of ‘online’ TMS, i.e., applying 
stimulation while participants were performing a task, as a potential means to further 
engage the stimulated network and produce stronger effect. She is now a Research 
Fellow at the NonInvasive Neuromodulation Unit (NNU) in the Experimental 
Therapeutics and Pathophysiology Branch of the National Institute of Mental Health, 
where she is combines two of these skill sets to apply TMS during cognitive therapy to 
improve outcomes in depressive disorders. Dr. Beynel is also exploring the potential 
of combining real-time fMRI neurofeedback with rTMS to achieve more precise control 
over brain state.